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SC 144

Product Name
SC 144
CAS No.
895158-95-9
Chemical Name
SC 144
Synonyms
SC144;SC 144;SC-144;CS-805;SC 144; SC144;SC144;SC-144;SC 144;2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide;N'-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)pyrazine-2-carbohydrazide;N'-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)-2-pyrazinecarbohydrazide;Pyrazinecarboxylic acid 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide
CBNumber
CB72666896
Molecular Formula
C16H11FN6O
Formula Weight
322.3
MOL File
895158-95-9.mol
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SC 144 Property

Density 
1.53±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in EtOH; insoluble in H2O; ≥16.1 mg/mL in DMSO
form 
solid
pka
8.87±0.43(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
S199000
Product name
SC144
Packaging
100mg
Price
$1680
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
48649
Product name
SC144
Packaging
100mg
Price
$2525
Updated
2021/12/16
Biorbyt Ltd
Product number
orb146229
Product name
SC144
Purity
>98%
Packaging
1g
Price
$2691.1
Updated
2021/12/16
AK Scientific
Product number
SYN5458
Product name
SC144 hydrochloride
Packaging
10mg
Price
$160
Updated
2021/12/16
ChemScene
Product number
CS-4440
Product name
SC144
Purity
98.60%
Packaging
25mg
Price
$170
Updated
2021/12/16
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SC 144 Chemical Properties,Usage,Production

Uses

SC144 is an orally active small-molecule gp130 inhibitor.

Biological Activity

sc144 is an inhibitor of gp130 with ic50 values of 0.43 μmol/l and 0.88 μmol/l in nci/adr-res and hey cell lines, respectively [1].sc144 is a first-in-class small-molecule gp130 inhibitor with oral activity in ovarian cancer. it can substantially increase the phosphorylation of gp130 (s782) in both ovcar-8 and caov-3 cells in a time- and dose-dependent manner. the increase phosphorylation then suppresses stat3 signaling pathway since the constitutive stat3 activation is maintained by extracellular gp130 ligands, besides that, sc144 also causes substantial cell apoptosis in these cells. [1].apart from the effect on gp130, it has been reported that sc144 can directly bind and stabilize il-24 in cancer cells. additionally, sc144 has shown to have effects on cell cycle perturbation and apoptosis induction [2].sc144 may also have other cellular protein targets, resulting in multiple potential molecular mechanisms. sc144’s anticancer potency may be a sum of these effects [2].

References

[1] shili xu, fedora grande, antonio garofalo, et al. discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer. molecular cancer therapeutics. 2013 (12): 937-949.
[2] shili xu, takashi oshima, toshio imada, munetaka masuda, bikash debnath, fedora grande, antonio garofalo, nouri neamati. stabilization of mda-7/il-24 for colon cancer therapy. cancer letters. 2013 feb(335):421-430.

SC 144 Preparation Products And Raw materials

Raw materials

Preparation Products

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SC 144 Suppliers

China 73 India 1 United States 11 Global 85
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
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58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
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60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4662
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60
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
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58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354
Email
support@targetmol.com
Country
United States
ProdList
19973
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58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9926
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65

895158-95-9, SC 144Related Search:

Pyrrole Trifluoroacetic acid 2,5-PYRIDINEDICARBOXYLIC ACID Octyl 4-methoxycinnamate Polyoxytrifluoro(trifluoromethyl)-1,2-ethanediyl, .alpha.-(1-carboxy-1,2,2,2-tetrafluoroethyl)-.omega.-tetrafluoro(trifluoromethyl)ethoxy- Bortezomib 2-METHOXYESTRADIOL PD 0325901 Belinostat (PXD101) Luminespib Crizotinib

  • 2-Pyrazinecarboxylic acid, 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide
  • 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide
  • SC 144
  • SC144
  • SC-144
  • Pyrazinecarboxylic acid 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide
  • SC 144; SC144
  • CS-805
  • SC144;SC-144;SC 144
  • N'-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)-2-pyrazinecarbohydrazide
  • N'-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)pyrazine-2-carbohydrazide
  • 895158-95-9
  • C16H11FN6O
  • Inhibitors